menopausal transition, the prevalence of metabolic syndrome increases
according to a new sketch by researchers at Rush University Medical Center.
The study suggests this crataegus oxycantha be a pathway by which cardiovascular disease
increases during climacteric. The written report is published in the July 28 issue of
the Archives of Internal Medicine, unitary of the JAMA/Archives journals.
Cardiovascular disease is the primary cause of death in women in Western
countries. Women tend to develop the disease about 10 years later than men
with a pronounced increase through the menopausal years. Cardiovascular disease
is rare among women younger than 45 years, but women elder than 55 years ar
more potential than men to let cardiovascular disease.
Metabolic syndrome is a summary measure of authoritative cardiovascular disease
risk factors that ofttimes coexist. The syndrome is evident in 20% to 30%
of middle-aged women and has been joined to the development of
cardiovascular disease and diabetes.
The longitudinal, 9-year-study of 949 participants in the Study of Women's
Health Across the Nation (SWAN) shows that the incidence of metabolic
syndrome increased progressively from six long time before to six long time after
the final menstrual period, independent of ripening and other known
cardiovascular disease danger factors. The increase is steeper during the
menopausal transition compared to the post menopausal years.
"Menopause-related testosterone predomination appears to be implicated as a
key hormonal change that is associated with the incidence of metabolic
syndrome," said lead investigator Imke Janssen, PhD, assistant professor,
Department of Preventive Medicine at Rush University Medical Center.
It was previously thought that estrogen exerted a direct positive result on
cardiovascular disease danger in women, a benefit that was lost as women
transitioned from a premenopausal to a postmenopausal state and experienced
a loss of estrogen.
"Our study information shows that the change in oestrogen level is, at best, a fallible
and nonsignificant predictor of metabolic syndrome risk," aforesaid Janssen. "A
more potential story is that the progressive testosterone predominance exerts a
mastermind negative issue on cardiovascular risk."
The SWAN study is a multiethnic, community -based, longitudinal cohort study
of the natural history of the menopausal passage in o'er 3300 women
enrolled in seven sites throughout the United States.
http://www.rush.edu
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